A/RES/72/198 International cooperation to address and counter the world drug problem challenges related to the world drug problem in a more comprehensive manner, in accordance with the principle of common and shared responsibility, including by means of enhanced and better-coordinated technical and financial assistance; 48. Takes note with appreciation of the 2016 report of the International Narcotics Control Board 17 and the supplementary reports thereto; 49. Invites Member States to strengthen, as appropriate, the proper functioning of national control systems and domestic assessment mechanisms and programmes, in cooperation with the International Narcotics Control Board, the United Nations Office on Drugs and Crime, the World Health Organization and other relevant United Nations system agencies, to identify, analyse and remove impediments to the availability and accessibility of controlled substances for medical and scientific purposes, within appropriate control mechanisms, as required by the three international drug control conventions and taking into account the publication entitled “Ensuring Balance in National Policies on Controlled Substances: Guidance for Availability and Accessibility of Controlled Medicines”, and, for that purpose, to consider the provision of technical and financial assistance, upon request, to developing countries; 50. Urges all Member States to enact comprehensive measures aimed at stemming the abuse, diversion and misuse of prescription drugs, in particular through the establishment of awareness-raising initiatives targeting the general public and health-care providers; 51. Recognizes that it is necessary for Member States, under the three international drug control conventions and the fundamental principles of their domestic legal systems and national legislation, to consider, where appropriate: (a) Regularly reviewing and assessing their drug control policies, ensuring that they are effective, comprehensive, balanced and aimed at pro moting the health and well-being of individuals, families, communities and society as a whole; (b) Providing, as appropriate, comprehensive, integrated drug demand reduction programmes, based on scientific evidence and covering a range of measures, including primary prevention, early intervention, treatment, care, rehabilitation, social reintegration and measures aimed at minimizing the negative public health and social impacts of drug abuse, aimed at promoting health and social well-being among individuals, families and communities and reducing the adverse consequences of drug abuse for individuals and society as a whole; 52. Calls upon the United Nations Office on Drugs and Crime, the International Narcotics Control Board, the World Health Organization and other United Nations entities with pertinent technical and operational expertise, within their mandates, to continue to provide, upon request, advice and assistance to States that are reviewing and updating their drug policies, in compliance with the three international drug control conventions, taking into account their national priorities and needs through, among other things, the promotion of the exchange of information and best practices on scientific evidence-based policies adopted by States; 53. Calls upon Member States to promote and strengthen the exchange of information and, as appropriate, drug-related criminal intelligence among law enforcement and border control agencies, including through the United Nations Office on Drugs and Crime multilateral portals and regional information centres and networks, and to promote joint investigations and coordinate operations, in conformity with national legislation, and training programmes at all levels, in order to identify, disrupt and dismantle organized criminal groups operating transnationally __________________ 17 12/21 International Narcotics Control Board, document E/INCB/2016/1. 17-23200