A/RES/65/1 climate change in accordance with the principles and provisions of the United Nations Framework Convention on Climate Change, 7 including the principle of common but differentiated responsibilities and respective capabilities. We maintain the Framework Convention as the primary international, intergovernmental forum for negotiating the global response to climate change. Addressing climate change will be of key importance in safeguarding and advancing progress towards achieving the Millennium Development Goals. 6F 27. We recognize that attention must be focused on the particular needs of developing countries and on the large and increasing economic and social inequalities. Disparities between developed and developing countries and inequalities between the rich and the poor, and between rural and urban populations, inter alia, remain persistent and significant and need to be addressed. 28. We recognize that policies and actions must focus on the poor and those living in the most vulnerable situations, including persons with disabilities, so that they may benefit from progress towards achieving the Millennium Development Goals. In this respect, there is a particular need to provide more equitable access to economic opportunities and social services. 29. We recognize the urgency of paying attention to the many developing countries with specific needs, and the unique challenges they confront in achieving the Millennium Development Goals. 30. We acknowledge that the least developed countries face significant constraints and structural impediments in their development efforts. We express grave concern that the least developed countries are lagging behind in meeting internationally agreed development goals, including the Millennium Development Goals. In that context, we call for continued implementation of the Brussels Programme of Action for the Least Developed Countries for the Decade 2001-2010 8 and look forward to the Fourth United Nations Conference on the Least Developed Countries, to be held in Istanbul, Turkey, in 2011, which would further invigorate the international partnership to address the special needs of these countries. 7F 31. We reiterate our recognition of the special needs of and challenges faced by the landlocked developing countries, caused by their lack of territorial access to the sea, aggravated by remoteness from world markets and also the concern that the economic growth and social well-being of landlocked developing countries remain very vulnerable to external shocks. We stress the need to overcome these vulnerabilities and build resilience. We call for the full, timely and effective implementation of the Almaty Programme of Action: Addressing the Special Needs of Landlocked Developing Countries within a New Global Framework for Transit Transport Cooperation for Landlocked and Transit Developing Countries, 9 as reaffirmed in the Declaration of the high-level meeting of the sixty-third session of the General Assembly on the midterm review of the Almaty Programme of Action. 10 8F 9F 32. We recognize the unique and particular vulnerabilities of small island developing States and reaffirm our commitment to take urgent and concrete action _______________ 7 United Nations, Treaty Series, vol. 1771, No. 30822. A/CONF.191/13, chap. II. 9 Report of the International Ministerial Conference of Landlocked and Transit Developing Countries and Donor Countries and International Financial and Development Institutions on Transit Transport Cooperation, Almaty, Kazakhstan, 28 and 29 August 2003 (A/CONF.202/3), annex I. 10 See resolution 63/2. 8 6